{"id":8,"date":"2019-01-07T19:28:00","date_gmt":"2019-01-07T19:28:00","guid":{"rendered":"https:\/\/canziolab.ucsf.edu\/?page_id=8"},"modified":"2026-02-20T22:46:16","modified_gmt":"2026-02-20T22:46:16","slug":"home","status":"publish","type":"page","link":"https:\/\/canziolab.ucsf.edu\/","title":{"rendered":"Home"},"content":{"rendered":"[vc_row][vc_column]\n\t\t\t<!-- START Homepage REVOLUTION SLIDER 6.7.21 --><p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t<rs-module-wrap id=\"rev_slider_1_1_wrapper\" data-source=\"gallery\" style=\"visibility:hidden;background:transparent;padding:0;margin:0px auto;margin-top:0;margin-bottom:0;\">\n\t\t\t\t<rs-module id=\"rev_slider_1_1\" style=\"\" data-version=\"6.7.21\">\n\t\t\t\t\t<rs-slides style=\"overflow: hidden; position: absolute;\">\n\t\t\t\t\t\t<rs-slide style=\"position: absolute;\" data-key=\"rs-1\" data-title=\"Slide\" data-anim=\"ms:600;r:0;\" data-in=\"o:0;\" data-out=\"a:false;\">\n\t\t\t\t\t\t\t<img src=\"\/\/canziolab.ucsf.edu\/wp-content\/plugins\/revslider\/sr6\/assets\/assets\/dummy.png\" alt=\"\" title=\"Home\" class=\"rev-slidebg tp-rs-img rs-lazyload\" data-lazyload=\"\/\/canziolab.ucsf.edu\/wp-content\/uploads\/2020\/01\/Header-Img.jpg\" data-parallax=\"5\" data-panzoom=\"d:30000;e:power0.in;ss:100;se:130;\" data-no-retina>\n<!--\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-1\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:c;y:m;yo:-58px,0,0,0;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:40;l:50;fw:800;a:center;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:949px,756px,756px,448px;h:70px,auto,auto,351px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:8690;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:5;font-family:'Raleway';\"\n\t\t\t\t\t\t\t>How do neurons recognize self from non-self? \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-4\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:c;xo:1px,0,0,0;y:m;yo:169px,253px,349px,270px;\"\n\t\t\t\t\t\t\t\tdata-text=\"l:22;fw:700;a:center;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:auto,auto,auto,405px;h:auto,auto,auto,61px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:8690;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:6;font-family:'Open Sans';\"\n\t\t\t\t\t\t\t>\"... Fatti non foste a viver come bruti ma per seguir virtute e canoscenza ...\" Dante, XXVI, 119 \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-1-layer-5\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:c;xo:-2px,0,0,0;yo:655px,667px,862px,656px;\"\n\t\t\t\t\t\t\t\tdata-text=\"l:22;a:inherit;\"\n\t\t\t\t\t\t\t\tdata-dim=\"h:32px,auto,auto,auto;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"sR:10;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:8690;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:7;font-family:'Open Sans';\"\n\t\t\t\t\t\t\t>\"... We were not born to live like brutes but to follow virtue and knowledge ...\" Dante, XXVI, 119 \n\t\t\t\t\t\t\t<\/rs-layer><!--\n-->\t\t\t\t\t<\/rs-slide>\n\t\t\t\t\t<\/rs-slides>\n\t\t\t\t<\/rs-module>\n\t\t\t\t<script>\n\t\t\t\t\tsetREVStartSize({c: 'rev_slider_1_1',rl:[1240,1024,778,480],el:[868,768,960,720],gw:[1240,1024,778,480],gh:[868,768,960,720],type:'hero',justify:'',layout:'fullwidth',mh:\"0\"});if (window.RS_MODULES!==undefined && window.RS_MODULES.modules!==undefined && window.RS_MODULES.modules[\"revslider11\"]!==undefined) {window.RS_MODULES.modules[\"revslider11\"].once = false;window.revapi1 = undefined;if (window.RS_MODULES.checkMinimal!==undefined) window.RS_MODULES.checkMinimal()}\n\t\t\t\t<\/script>\n\t\t\t<\/rs-module-wrap>\n\t\t\t<!-- END REVOLUTION SLIDER -->\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; content_placement=&#8221;middle&#8221; el_id=&#8221;research&#8221;][vc_column][vc_empty_space height=&#8221;64px&#8221;][vc_single_image image=&#8221;272&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;]<div id=\"argenta-custom-69d6d6e68fcfd\"  >\n\t<p style=\"text-align: center;\">Research<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;]<div id=\"argenta-custom-69d6d6e68ff53\"  >\n\t<p style=\"text-align: center;\">The role of cell surface diversity in neural circuit assembly<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;]<div id=\"argenta-custom-69d6d6e69009b\"  >\n\t<p style=\"text-align: center;\">During brain development, the assembly of functional neural circuits requires mechanisms to connect different neurons.\u0003 Crucial to this process is the ability of neurites (axons and dendrites) of individual neurons to distinguish between themselves and neurites from other neurons. This mechanism is known as self-avoidance and requires that, in principle, every neuron must express a unique combination of cell-surface recognition molecules to generate a molecular recognition code, i.e. an identity.<\/p>\n<p style=\"text-align: center;\"><strong>The long-term goal of our laboratory is to dissect the molecular mechanisms behind the generation of such code in mammals.<\/strong><\/p>\n<\/div>\n\n[vc_single_image image=&#8221;321&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][vc_empty_space][\/vc_column][\/vc_row][vc_row content_placement=&#8221;middle&#8221; css=&#8221;.vc_custom_1578752822970{padding-right: 30px !important;padding-left: 30px !important;background-color: #ebeef0 !important;}&#8221;][vc_column][vc_empty_space height=&#8221;8px&#8221;]<div id=\"argenta-custom-69d6d6e6901ad\"  >\n\t<p style=\"text-align: center;\">Clustered Protocadherins genes: a code for neural cell-surface diversity<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;]<div id=\"argenta-custom-69d6d6e6902ca\"  >\n\t<p style=\"text-align: center;\">In mammals, the generation of cell-surface diversity requires stochastic and combinatorial expression of a small subset of clustered Protocadherin (Pcdh) genes, randomly chosen from a total of 60. \u0003This is a remarkable task especially given that these 60 nearly-identical genes are organized in tandem and are sequestered within a chromatin state, doubly locked by DNA and H3K9 methylation and thus generally refractive to transcription.<\/p>\n<p style=\"text-align: center;\">At the core of such elegant mechanism for the generation of protein isoform diversity, two fundamental questions remained unanswered: How is random choice of a small number of nearly identical genes achieved? How does localized expression occur in a repressive environment? We use genomic, genetics, biochemical and biophysical approaches to dissect the exquisite coupling between the 3D chromosome architecture, the underlying chromatin structure, transcription and RNA processing that enables \u0003the generation of such enormous diversity of molecular identities in neurons.<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;16px&#8221;][vc_single_image image=&#8221;324&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;]<div id=\"argenta-custom-69d6d6e6903d1\"  >\n\t<p style=\"text-align: center;\"><em>\u201cThe Pcdh gene cluster: an architectural masterpiece\u201d T. Maniatis<\/em><\/p>\n<\/div>\n\n[vc_empty_space][\/vc_column][\/vc_row][vc_row content_placement=&#8221;middle&#8221; css=&#8221;.vc_custom_1578750440983{background-color: #ffffff !important;}&#8221; el_id=&#8221;publications&#8221;][vc_column][vc_single_image image=&#8221;272&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;]<div id=\"argenta-custom-69d6d6e6904c9\"  >\n\t<p style=\"text-align: center;\">Publications<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1578752207615{padding-top: 10px !important;padding-right: 20px !important;padding-bottom: 10px !important;padding-left: 20px !important;background-color: #ebeef0 !important;}&#8221;][vc_column]<div id=\"argenta-custom-69d6d6e6905d2\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p style=\"text-align: left;\"><em><strong>Gene Clusters Reveal Fundamental Principles of Genome Folding and Transcriptional Regulation<\/strong><\/em><\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e6906d5\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p><a href=\"https:\/\/www.annualreviews.org\/docserver\/fulltext\/cellbio\/41\/1\/annurev-cellbio-111822-122324.pdf?expires=1768330007&amp;id=id&amp;accname=ar-229713&amp;checksum=8CC3768F2D586991B12E521268BD1954\"><i><u>Annual Reviews<\/u><\/i><\/a> (2025)<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e6907d4\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><b>Buckley A., Vetralla C., Canzio D.<\/b><\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1687911623440{padding-top: 10px !important;padding-right: 20px !important;padding-bottom: 10px !important;padding-left: 20px !important;background-color: #d7dee1 !important;}&#8221;][vc_column]<div id=\"argenta-custom-69d6d6e6908d7\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><em><strong>Tuning cohesin trajectories enables differential readout of the Pcdh<b>\u03b1<\/b> cluster across neurons<\/strong><\/em><\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e6909f1\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p><a href=\"https:\/\/www.science.org\/stoken\/author-tokens\/ST-2038\/full\"><i><u>Science<\/u> <\/i><\/a>(2024)<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e690b46\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><b>Kiefer L.*, Gaudin S.*, Rajkumar S.M., Servito G.I.F., Langen J., Mui M.H., Nawsheen S., Canzio D.<\/b><\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1578752207615{padding-top: 10px !important;padding-right: 20px !important;padding-bottom: 10px !important;padding-left: 20px !important;background-color: #ebeef0 !important;}&#8221;][vc_column]<div id=\"argenta-custom-69d6d6e690c49\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p style=\"text-align: left;\"><em><strong>WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring<\/strong><\/em><\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e690d40\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.science.org\/stoken\/author-tokens\/ST-1286\/full\"><em>Science<\/em><\/a><\/span> (2023)<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e690e52\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><b>Kiefer L.<\/b>*, <b>Chiosso A.<\/b>*, <b>Langen J.<\/b>*, <b>Buckley A.*, Gaudin S.,<\/b> <b>Rajkumar S.M.<\/b>\u2020<b>,<\/b>\u00a0<b>Servito G.I.F.<\/b>\u2020, <b>Cha E.S.<\/b>, <b>Vijay A<\/b>., <b>Yeung A.<\/b>, Horta A., <b>Mui M.H.<\/b>, <b>Canzio D<\/b>.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1687911623440{padding-top: 10px !important;padding-right: 20px !important;padding-bottom: 10px !important;padding-left: 20px !important;background-color: #d7dee1 !important;}&#8221;][vc_column]<div id=\"argenta-custom-69d6d6e690f7f\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><em><strong>Cohesin erases genomic-proximity biases to drive stochastic Protocadherin expression for proper neural wiring<\/strong><\/em><\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e691078\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.03.09.483674v1\"><i><u>bioRxiv<\/u> <\/i><\/a>(2021)<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e691180\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><b>Kiefer L.<\/b>*, <b>Servito G.I.F.<\/b>*, <b>Rajkumar S.M.<\/b>*, <b>Langen J.<\/b>*, <b>Chiosso A.<\/b>*, <b>Buckley A.<\/b>, <b>Cha E.S.<\/b>, Horta A., <b>Mui M.H.<\/b>, <b>Canzio D<\/b>.<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1578752207615{padding-top: 10px !important;padding-right: 20px !important;padding-bottom: 10px !important;padding-left: 20px !important;background-color: #ebeef0 !important;}&#8221;][vc_column]<div id=\"argenta-custom-69d6d6e69127f\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><em><strong>Antisense lncRNA transcription mediates DNA demethylation to drive stochastic Protocadherin <b>\u03b1<\/b> promoter choice<\/strong><\/em><\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e691376\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(19)30270-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419302703%3Fshowall%3Dtrue\"><span style=\"text-decoration: underline;\"><em>Cell<\/em><\/span><\/a> (2019)<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e69147c\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><b>Canzio D.,<\/b> Nwakeze C., Horta A., <strong>Rajkumar S.<\/strong>, Coffey E., Duffy E., Duffie\u2019 R., Monahan K., O\u2019Keeffe S., Simon M., Lomvardas S., Maniatis T.<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1687911623440{padding-top: 10px !important;padding-right: 20px !important;padding-bottom: 10px !important;padding-left: 20px !important;background-color: #d7dee1 !important;}&#8221;][vc_column]<div id=\"argenta-custom-69d6d6e691576\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><em><strong>Clustered Protocadherin methylation alterations in cancer<\/strong><\/em><\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e691672\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p><a href=\"https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/10.1186\/s13148-019-0695-0\"><em><span style=\"text-decoration: underline;\">Clinical Epigenetics<\/span><\/em><\/a> (2019)<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e691769\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\">Vega-Benedetti A.F., Loi E., Moi L., Blois S., Fadda A., Antonelli M., Arcella A., Badiali M., Giangaspero F., Morra I., Columbano A., Restivo A., Zorcolo L., Gismondi V., Varesco L., Bellomo S.K., Giordano S., Canale M., Casadei-Gardini A., Faloppi L., Puzzoni M., Scartozzi M., Ziranu P., Cabras G., Cocco P., Ennas M. G., Satta G., Zucca M., <b>Canzio D.,<\/b> Zavattari P.<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1578752207615{padding-top: 10px !important;padding-right: 20px !important;padding-bottom: 10px !important;padding-left: 20px !important;background-color: #ebeef0 !important;}&#8221;][vc_column]<div id=\"argenta-custom-69d6d6e69185f\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><em><strong>The generation of a Protocadherin cell-surface recognition code for neural circuit assembly<\/strong><\/em><\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e691953\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31710891\/\"><span style=\"text-decoration: underline;\"><em>Current Opinion in Neurobiology<\/em><\/span><\/a> (2019)<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e691a44\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\"><b>Canzio D.,\u00a0<\/b>Maniatis T.<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1687911623440{padding-top: 10px !important;padding-right: 20px !important;padding-bottom: 10px !important;padding-left: 20px !important;background-color: #d7dee1 !important;}&#8221;][vc_column]<div id=\"argenta-custom-69d6d6e691b35\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p><em><strong>Writing, reading, and translating the clustered Protocadherin cell surface recognition code for neural circuit assembly<\/strong><\/em><\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e691c26\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30296392\/\"><em><span style=\"text-decoration: underline;\">Annual Review of Cell and Developmental Biology<\/span><\/em><\/a> (2018)<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e691d25\" class=\"text-wrapper body, p { color: #fff; }\"  >\n\t<p class=\"p1\">Mountoufaris G., <b>Canzio D.,<\/b> Nwakeze CL., Chen WV., Maniatis T.<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row content_placement=&#8221;middle&#8221; css=&#8221;.vc_custom_1578752441939{background-color: #ffffff !important;}&#8221; el_id=&#8221;team&#8221;][vc_column][vc_empty_space height=&#8221;8px&#8221;][vc_single_image image=&#8221;272&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;]<div id=\"argenta-custom-69d6d6e691e13\"  >\n\t<p style=\"text-align: center;\">Join the team<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;]<div id=\"argenta-custom-69d6d6e691f33\"  >\n\t<p style=\"text-align: center;\">Please contact us if you are interested in joining the team.<br \/>\nWe are recruiting research assistants, graduate students and postdocs!<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/5&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/5&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/5&#8243;]<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:Daniele.Canzio@ucsf.edu\" class=\"btn btn-rounded btn-large full-width\" id=\"argenta-custom-69d6d6e692085\">\n\t\t\t\t<span class=\"text\">JOIN US<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column_inner][vc_column_inner width=&#8221;1\/5&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/5&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;356&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e6921ec\"  >\n\t<p style=\"text-align: left;\"><strong>Daniele Canzio<\/strong><br \/>\nAssociate Professor<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e6922f9\"  >\n\t<p>Daniele was born in Rieti, Italy. He received his Bachelor of Science in Biochemistry from the University of California, Santa Barbara and his PhD in Chemical Biology from the University of California, San Francisco under the guidance of Dr. Geeta Narlikar. He then moved to New York City for his postdoctoral training in the laboratory of Tom Maniatis at Columbia University. When not in lab, Daniele loves riding his bike and spending time with Mocha.<\/p>\n<\/div>\n\n<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:Daniele.Canzio@ucsf.edu\" class=\"btn btn-rounded\" id=\"argenta-custom-69d6d6e692428\">\n\t\t\t\t<span class=\"text\">Get in touch<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;492&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e69256f\"  >\n\t<p style=\"text-align: left;\"><strong>Alexander Greben<\/strong><br \/>\nPostdoctoral fellow<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e6926ab\"  >\n\t<div id=\"message-list_1768505943.159969\" aria-setsize=\"-1\">\n<div>\n<div aria-roledescription=\"message\">\n<div>\n<div>\n<div>\n<div>\n<div>\n<div>\n<div>\n<div>\n<div>Alexander was born and raised in Toronto, Canada. He received a bachelor\u2019s degree in Neuroscience from McGill University in Montr\u00e9al, then moved to Harvard University to pursue a PhD in Neuroscience in the lab of Michael Greenberg. In the lab, Alexander is interested in how chromatin shapes gene regulation and protocadherin specificity. Outside of the lab, Alexander likes photography, film, food, and learning to play tennis.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:alexander.greben@ucsf.edu\" class=\"btn btn-rounded\" id=\"argenta-custom-69d6d6e6927db\">\n\t\t\t\t<span class=\"text\">Get in touch<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;486&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e692924\"  >\n\t<p style=\"text-align: left;\"><strong>Jennifer Langen<\/strong><br \/>\nUCSF, Neuroscience Graduate Student<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e692a25\"  >\n\t<p>Jenn was born and raised in Pasadena, a suburb of Los Angeles, CA. She attended the University of Southern California for her undergraduate studies, where she received her B.A. in Neuroscience. Before relocating to the Bay Area as a Neuroscience PhD student, she worked as an undergraduate researcher and lab technician with Dr. Karen Chang at USC. When not thinking about clustered Protocadherins, Jenn keeps herself busy with random artistic pursuits and baking.<\/p>\n<\/div>\n\n<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:Jennifer.Langen@ucsf.edu\" class=\"btn btn-rounded\" id=\"argenta-custom-69d6d6e692b4f\">\n\t\t\t\t<span class=\"text\">Get in touch<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;483&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e692ca6\"  >\n\t<p style=\"text-align: left;\"><strong>Alex Buckley<\/strong><br \/>\nUCSF, Neuroscience Graduate Student<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e692dc5\"  >\n\t<p data-pm-slice=\"1 1 []\">Alex grew up in the San Francisco Bay Area and went to undergrad at Washington University in St. Louis. He then teched for two years in the lab of Evan Macosko at the Broad Institute before joining the neuroscience program at UCSF. His interest in how neurons acquire their intricate morphologies and wiring patterns drew him to the study of protocadherins. He loves playing tennis, exploring new places, and going on coffee runs with his lab mates.<\/p>\n<\/div>\n\n<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:Alex.Buckley@ucsf.edu\" class=\"btn btn-rounded\" id=\"argenta-custom-69d6d6e692f1a\">\n\t\t\t\t<span class=\"text\">Get in touch<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;461&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e693063\"  >\n\t<p style=\"text-align: left;\"><b>Carlo Vetralla<\/b><br \/>\nUCSF, Tetrad Graduate Student<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e693172\"  >\n\t<p>Carlo was born in Milan, Italy, where he completed his Bachelor\u2019s and Master\u2019s degrees in Medical Biotechnologies. During his thesis, he worked in the Tjian-Darzacq lab at UC Berkeley and later returned to the Bay Area to start a PhD at UCSF in the Tetrad program. In the Canzio lab, he is passionate about enhancer-promoter communication and the dynamics of cohesin loop extrusion in the protocadherin locus. When not in the lab, you can find Carlo in the gym or watching Ac Milan play.<\/p>\n<\/div>\n\n<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:Carlo.Vetralla@ucsf.edu\" class=\"btn btn-rounded\" id=\"argenta-custom-69d6d6e6932f5\">\n\t\t\t\t<span class=\"text\">Get in touch<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;381&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e693449\"  >\n\t<p style=\"text-align: left;\"><b>Michael Mui<\/b><br \/>\nResearch Assistant<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e693548\"  >\n\t<p>Michael was born in Hong Kong and was raised in San Francisco, CA. He received his B.S. in Animal Science from UC Davis. Prior to joining the Canzio lab, he was an animal technician at UCSF. Michael is joined between the Canzio and the Paredes labs at UCSF. When not in lab, Michael likes to watch movies, draw, and spend time with his dog.<\/p>\n<\/div>\n\n<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:Michael.Mui@ucsf.edu\" class=\"btn btn-rounded\" id=\"argenta-custom-69d6d6e69366a\">\n\t\t\t\t<span class=\"text\">Get in touch<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;488&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e6937bd\"  >\n\t<p style=\"text-align: left;\"><b>Matthew Fiedeldey<\/b><br \/>\nJunior Specialist<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e6938bd\"  >\n\t<p>Matthew was born and raised in Indianapolis, Indiana before moving to the Bay Area to pursue a B.S. in Molecular Environmental Biology from UC Berkeley. There he worked in the lab of Prof. Hillel Adesnik to better understand how cortical circuits give rise to conscious perception. When not in the lab, he is most likely at jiu-jitsu, working on robotics projects, or riding a motorcycle.<\/p>\n<\/div>\n\n<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:matthew.fiedeldey@ucsf.edu\" class=\"btn btn-rounded\" id=\"argenta-custom-69d6d6e6939dc\">\n\t\t\t\t<span class=\"text\">Get in touch<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;485&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e693b1e\"  >\n\t<p style=\"text-align: left;\"><b>Jash Gada<\/b><br \/>\nJunior Specialist<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e693c1e\"  >\n\t<p>Jash grew up in the San Francisco Bay Area before heading down to the University of Southern California where he completed his B.S. in Human Biology. There, he worked under Dr. Derrick Morton to better understand the role of the RNA exosome in neurodevelopment through a cerebellar organoid model. When not in lab, he can be found at the gym, the basketball court, or on the Caltrain.<\/p>\n<\/div>\n\n<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:jash.gada@ucsf.edu\" class=\"btn btn-rounded\" id=\"argenta-custom-69d6d6e693d57\">\n\t\t\t\t<span class=\"text\">Get in touch<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;487&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e693ebd\"  >\n\t<p style=\"text-align: left;\"><b>Shayra Nawsheen<\/b><br \/>\nSpecialist<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e693fc1\"  >\n\t<p>Shayra was born in Bangladesh and grew up in Los Angeles, California. She went to UC Berkeley for her undergraduate where she majored in Molecular and Cell Biology with an emphasis on Neurobiology. She then moved to San Diego to pursue her masters in Bioengineering at UC San Diego. She initially joined the lab as an undergraduate volunteer in 2023 and has decided to rejoin the lab as a research assistant again in 2026 after completing her masters. Outside the lab, Shayra can be found exploring new cafes, watching horror movies, and traveling.<\/p>\n<\/div>\n\n<div class=\"button_wrapper\"  >\n\t\n\t<a href=\"mailto:jash.gada@ucsf.edu\" class=\"btn btn-rounded\" id=\"argenta-custom-69d6d6e6940dd\">\n\t\t\t\t<span class=\"text\">Get in touch<\/span>\n\t\t\t<\/a>\n\t\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;300&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"argenta-custom-69d6d6e69422d\"  >\n\t<p style=\"text-align: left;\"><strong>Mocha<\/strong><br \/>\nFluffy friend<\/p>\n<\/div>\n\n<div id=\"argenta-custom-69d6d6e694331\"  >\n\t<p style=\"text-align: left;\">Mocha is a New Yorker. Prior to joining the Canzio lab she \u201cworked\u201d as a happy doggie in Daniele\u2019s house.<\/p>\n<\/div>\n\n[\/vc_column][\/vc_row][vc_row content_placement=&#8221;middle&#8221; css=&#8221;.vc_custom_1684529716552{background-color: #ffffff !important;}&#8221;][vc_column][vc_single_image image=&#8221;272&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;]<div id=\"argenta-custom-69d6d6e694426\"  >\n\t<p style=\"text-align: center;\">Lab Alumni<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][vc_column_text]\n<h6><strong>Sandy Rajkumar<\/strong> (PhD student in Biochemistry, Cell &amp; Molecular Biology, Weill Cornell)<\/h6>\n<h6>Gabrielle Servito (PhD student in Chemical Biology, Biochemistry, &amp; Biophysics, UC Santa Cruz)<\/h6>\n<h6>Lisa Cha (MD\/PhD student, UCLA)<\/h6>\n<h6>Anna Chiosso (PhD student in Neuroscience, University of Zurich)<\/h6>\n<h6>Akshara Vijay (PhD Student, University of Pittsburgh)<\/h6>\n<h6>Albert Yeung (Research Technician, University of Pennsylvania)<\/h6>\n<h6>Simon Gaudin (PhD student in Genetics, Stanford)<\/h6>\n<h6>Lea Kiefer (Scientist II, Scribe Therapeutics)<\/h6>\n<h6>Jaden Lucas-Retherford (Law Student, St. John&#8217;s School of Law, New York)<\/h6>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row content_placement=&#8221;middle&#8221; css=&#8221;.vc_custom_1684529731089{background-color: #ffffff !important;}&#8221; el_id=&#8221;findus&#8221;][vc_column][vc_empty_space][vc_single_image image=&#8221;272&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;]<div id=\"argenta-custom-69d6d6e694519\"  >\n\t<p style=\"text-align: center;\">Find us<\/p>\n<\/div>\n\n[vc_empty_space height=&#8221;8px&#8221;][vc_single_image image=&#8221;305&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;]<div id=\"argenta-custom-69d6d6e694623\"  >\n\t<p style=\"text-align: center;\"><strong>UCSF Weill Institute for Neurosciences<br \/>\n<\/strong>1651 4th Street, 4th floor<br \/>\nSan Francisco, CA, 94158, USA<\/p>\n<\/div>\n\n[vc_empty_space][vc_gmaps link=&#8221;#E-8_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&#8221;][vc_empty_space height=&#8221;8px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1578755192613{background-color: #ebeef0 !important;}&#8221;][vc_column width=&#8221;1\/3&#8243;]<div id=\"argenta-custom-69d6d6e69471b\"  >\n\t<p style=\"text-align: center;\">Department of Neurology<br \/>\n<a href=\"https:\/\/neurology.ucsf.edu\"><strong>Get in touch &gt;<\/strong><\/a><\/p>\n<\/div>\n\n[vc_empty_space][\/vc_column][vc_column width=&#8221;1\/3&#8243;]<div id=\"argenta-custom-69d6d6e69480d\"  >\n\t<p style=\"text-align: center;\">Dep of Biochemistry &amp; Biophysics<br \/>\n<a href=\"http:\/\/biochemistry.ucsf.edu\/index.php\"><strong>Get in touch &gt;<\/strong><\/a><\/p>\n<\/div>\n\n[vc_empty_space][\/vc_column][vc_column width=&#8221;1\/3&#8243;]<div id=\"argenta-custom-69d6d6e6948ff\"  >\n\t<p style=\"text-align: center;\">Dep of Psychiatry<br \/>\n<a href=\"https:\/\/psych.ucsf.edu\"><strong>Get in touch &gt;<\/strong><\/a><\/p>\n<\/div>\n\n[vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; content_placement=&#8221;middle&#8221; el_id=&#8221;research&#8221;][vc_column][vc_empty_space height=&#8221;64px&#8221;][vc_single_image image=&#8221;272&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][vc_empty_space height=&#8221;8px&#8221;][vc_empty_space height=&#8221;8px&#8221;][vc_single_image image=&#8221;321&#8243; 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